55.Pervin K, Childerstone A, Shinnick T, Mizushima Y, van der Zee,Vaughan R, Lehner T.T cell epitope expression of myobacterial and homologous human 65kD heat shock protein peptides in short term cell lines from patients with Behcet's disease. J Immunol 151(4) : 2273-2282, 1993.

56.Yanagawa A, Takano K, Nishioka K, Shimada G, Mizushima Y, Ashida H.Clinical staging and gadolinium-DTPA enhanced images of the wrist in rheumatoid arthritis.J Rheumatol 20,781-784,1993.

57.Nakajima T, Kitamura K, Yamashita N, Sakane T, Mizushima Y, Delespesse G, Lel RB.Constitutive expression and production of tumor necrosis factor-s in T-cell lines infected with HTLV-I and HTLV-II. Biochem Biopys Res Commun 19,371-377, 1993.

58.Takeno M. Suzuki N. Nagafuchi H, Mizushima Y, Sakane T.Selective suppression of resting B cell function in patients with systemic lupus erythematosus treated with cyclophosphamide. Clin Exp Rheum 11,263-270, 1993.

59.Suzuki N, Harada T, Mizushima Y, Sakane T.Possible pathogenic role of cationic Anti-DNA autoantibodies in the development of nephritis in patients with systemic lupus erythematosus. J Immunol 151,1128-1136, 1993.

60.Okubo M, Yamamoto K, Kato K, Matsuura N, Nishimaki T, Kasukawa R, Ito K, Mizuishima Y, Nishioka K.Detection and epitope analysis of the autoantigen-reactive T cells to the U1-nuclear ribonucleoprotein A Protein in autoimmune diseases patients. J Immunol 151,1108-1115, 1993.

61.Yamashita N, Nakajima T, Takahashi H, Kaneoka H, Mizushima Y, Sakane T.Effect of active in A on IgE synthesis and cytokine production in Human peripheral mononuclear cells. Clin Exp Immunol 94,214-219 1993.

62.Nagafuchi H, Suzuki N, Mizushima Y, Sakane T.Constitutive expression on IL-6 receptors and their role in the excessive B cell function in patients with systemic lupus erythematosus. J Immunol 151,6525-6534, 1993.

63.Takenaga M, Igarashi R, Tsuji H, Mizushima Y. Enhanced antitumor activity and reduced toxicity of 1, 3-bis (2-chloroethyl)-1-nitrosourea administered in lipid microspheres to tumor-bearing mice. Jpn J Cancer Res. 84: 1078-1085, 1993.

64.Toyota T, Hirata Y, Ikeda Y, Matsuoka K, Sakuma A, Mizushima Y. Lipo-PGE1, A new lipid-encapsulated preparation of prostaglandin E1: Placebo-and prostaglandin E1-controlled multicenter trials in patients with diabetic neuropathy and leg ulcers. Prostaglandins 46:453-468, 1993.

65.Takenaga M, Nakagawa T, Igarashi R, Mizushima Y.Application of lipid microspheres to prepare a thromboxane A2 receptor antagonist aerosol for inhalation. J Drug Targeting 1: 293-301, 1993.

66.Mizushima Y, Hoshi,K. Recent advances in lipid microsphere technology for targeting prostaglandin delivery (Review). J Drug Targeting 1:93-100,1993.

67. Mizushima Y, Toyota T, Okita K, Ohtomo E. Recent clinical studies on lipo-PG1 and lipo-PG12 and PG12 incroporated in lipid
microspheres,for targeted delivery (Review). J Controlled Release 28:243-249, 1994.

68.Stanford MR, Kasp E, Whiston R, Hasan A, Todryk S, Shinnick T, Mizushima Y, Dumonde DC, van der Zee R, Lehner T. Heat shock protein peptides reactive in patients with Bechet's disease are uveitogenic in Lewis rats: Clin Exp Immunol 97:226-231, 1994.

69.Igarashi R, Hoshino J, Ochiai A, Morizawa Y, Mizushima Y.Lecithinized superoxide dismutase enhances its pharmacological potency by increasing its cell membrane affinity. J Pharmacol Exper Ther 271,1672-1677, 1994.

70.Lehner T, Childerstone A, Pervin K, Hasan A, Direskeneli H, Stanford M R, Whiston R, Dumonde D C, Shinnick T, Van der zee R, Mizushima Y.Stress proteins in Behcet's diseases and experimental uveitis. Stress Proteins in Medicine, 1995.

71.Hasan A, Childerstone A, Pervin K , Shinnick T, Mizushima Y, Van der Zee R., Vaughan R, Lehner T.Recognition of a unique peptide epitope of the myobacterial and human heat shock protein 65-60 antigen by T cells of patients with recurrent oral ulcers. Clin Exp Immun 99,392-397, 1995.

71.Hasan A, Fortune F, Wilson A, Warr K, Shinnick T, Mizushima Y, R.Van der Zee, Stanford M, Sanderson T, Lehner T. Role of T cells in pathogenesis and diagnosis of Behcet's disease. Lancet 347, 789-794, 1996.

72.Nakai D, Seita T, Terasaki T, Iwasa S, Shoji Y, Mizushima Y, Sugiyama Y..Cellular uptake mechanism for oligonucleotides: involvement of endocytosis in the uptake of phosphodiester oligonucleotides by a human colorectal adenocarcinoma cell line, HCT-15: J Pharmacol Exp Ther 278 (3),1362-1372, 1996.


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